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Dengue Hemorrhagic Fever Model may Need a Rethink

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The dogma of the antibody-dependent enhancement model (ADE) for the development of dengue hemorrhagic fever (DHF) is being challenged by research published this week in IPLoS Medicine/I. Dengue virus infection usually causes a severe 'flu like illness, although symptoms may be mild in young children. DHF, however, is a severe and sometimes fatal complication of dengue virus infection that affects about half a million people every year. DHF patients usually fall into two groups; children ...

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